Product Preparation
A synthetic peptide corresponding to N-term of the cleavage formVLLKRHHQR of human FVIII protein. It also identical to mouse, chicken origin.
Background
The Coagulation Factor VIII (FVIII) is a glycoprotein essential for the intrinsic pathway of blood coagulation. A mature form of FVIII is a single-chain, 2351 amino acid polypeptide with a MW 265kDa. The FVIII can be activated by proteolytic cleavage intracellularlyinto a two-chain heterodimer, a heavy-chain and light-chain.The development of anti-factor VIII (FVIII) antibodies is currently one of the most serious complications in the treatment of haemophilia A patients due to the nature and properties of anti-FVIII antibodies, their mechanism of action, their neutralization by anti-idiotypic antibodies, and the role of T cells in FVIII inhibitor formation.
Applications/Suggested Working Dilutions
| | Immunoprecipitation 2-5µg/ml | | |
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